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Antigenic Specificity | Smac (CT) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunoblot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Anti-Smac (CT) [Rabbit antibody to peptide corresponding to aa 225-239 of human Smac.]. This antibody recognizes human, mouse, and rat Smac (25 kD). Inhibitors of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases has been identified and designated Smac/DIABLO. Smac is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. The Nterminal amino acids of Smac are required for binding to IAPs and for activation of caspases. Smac is expressed in a variety of human and mouse tissues. |
Immunogen | Antigen: Peptide corresponding to aa 225- 239 of human Smac. |
Other Names | [Smac (CT); Smac/DIABLO (CT)], [DIABLO; SMAC; SMAC3; DIABLO-S; FLJ10537; FLJ25049] |
Gene, Accession # | Gene ID: 56616, UniProt: Q53HB7 |
Catalog # | MBS194139 |
Price | $415 |
Order / More Info | Smac (CT) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |