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Antigenic Specificity | OAS1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-364 of human OAS1 (NP 002525.2). |
Other Names | [OIAS; IFI-4; OIASI; E18/E16] |
Gene, Accession # | [OAS1], Gene ID: 4938, NCBI: P00973.4, UniProt: P00973 |
Catalog # | MBS8544966 |
Price | $280 |
Order / More Info | OAS1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |