CKLF6 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CKLF6 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: CKLF6 antibody detects endogenous levels of total CKLF6. Function: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.Subunit Structure: Interacts with PD-L1/CD274 (via transmembrane domain); the interaction is direct |
| Immunogen | Immunogen: A synthesized peptide Subcellular Location: Membrane. Tissue Specificity: Expressed in the leukocytes, placenta and testis. Predicted Cross Reactivity: Horse, Rabbit Similarity: Horse (91%), Rabbit (100%) |
| Other Names | [chemokine like factor super family 6; chemokine like factor superfamily 6; chemokine like factor superfamily member 6; Chemokine-like factor superfamily member 6; CKLF like MARVEL transmembrane domain containing 6; CKLF-like MARVEL transmembrane domain-containing protein 6; CKLF6_HUMAN; CKLFSF6; Cmtm6; Da2 17; LRRGT00102; PRO2219] |
| Gene, Accession # | [CKLF6], Gene ID: 54918, NCBI: NP_060271.1, UniProt: Q9NX76 |
| Catalog # | MBS9605400 |
| Price | $240, $280 |
| Order / More Info | CKLF6 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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