Description | Specificity: No cross reactivity with other proteins. Description: Rabbit IgG polyclonal antibody for Interleukin 34/IL34 detection. Tested with WB, IHC-P in Human; Mouse; Rat.Background: Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor. This gene is mapped to 16q22.1. |
Product Specific References | 1. Gross, M. B. Personal Communication. Baltimore, Md. 5/30/2014. 2. Lin, H., Lee, E., Hestir, K., Leo, C., Huang, M., Bosch, E., Halenbeck, R., Wu, G., Zhou, A., Behrens, D., Hollenbaugh, D., Linnemann, T., Qin, M., Wong, J., Chu, K., Doberstein, S. K., Williams, L. T. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320: 807-811, 2008. |