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Antigenic Specificity | Integrin alpha 4 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Integrin alpha-4(ITGA4) detection. Tested with WB, IHC-P in Human;Rat. Background: ITGA4/Integrin alpha4 is an integrin alpha subunit. It makes up half of the alpha4beta1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. ITGA4 is also mapped to 2q31-q32 by fluorescence in situ hybridization. |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 4 (999-1028aa MWKAGFFKRQYKSILQEENRRDSWSYINS K), different from the related mouse sequence by one amino acid. Ig Type: Rabbit IgG |
Other Names | [Integrin alpha-4; 269C wild type; Alpha 4 subunit of VLA 4 receptor; Antigen CD49D; Antigen CD49D, alpha 4 subunit of VLA 4 receptor; CD 49d; CD49 antigen like family member D; CD49 antigen-like family member D; CD49d; CD49d antigen; CDw49d; IA4; Integrin alpha 4; Integrin alpha 4 subunit; Integrin alpha IV; Integrin alpha-4; Integrin alpha-IV; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor); ITA4_HUMAN; ITGA 4; ITGA4; LPAM23; MGC90518; OTTHUMP00000205320; Very Late Activation Antigen 4; Very Late Activation Protein 4 Receptor Alpha 4 Subunit; Very late activation protein 4 receptor, alpha 4 subunit; VLA 4; VLA 4 subunit alpha; VLA-4 subunit alpha; VLA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)], [ITGA4; ITGA4; IA4; CD49D; CD49D] |
Gene, Accession # | Gene ID: 3676, NCBI: NP_000876.3, UniProt: P13612 |
Catalog # | MBS178144 |
Price | $315 |
Order / More Info | Integrin alpha 4 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Jaspers, M., Zhang, Z., Marynen, P., Vekemans, S., Aly, M. S., Cuppens, H., Hillicker, C., Cassiman, J.-J.Localization of the genes encoding the alpha-2 and alpha-4 subunits of the human VLA-receptors to chromosome 5q23-31 and 2q31-32 respectively. (Abstract)Cytogenet. Cell Genet. 58: 1870 only, 1991. 2. Miller, D. H., Khan, O. A., Sheremata, W. A., Blumhardt, L. D., Rice, G. P. A., Libonati, M. A., Willmer-Hulme, A. J., Dalton, C. M., Miszkiel, K. A., O'Connor, P. W.A controlled trial of natalizumab for relapsing multiple sclerosis.New Eng. J. Med. 348: 15-23, 2003. |