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Antigenic Specificity | INSR (Insulin Receptor) (N-term), 21-52 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse, rat) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 1.48 |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This INSR(Insulin Receptor) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-52 amino acids from the N-terminal region of human INSR(Insulin Receptor). INSR is a receptor that binds insulin and has a tyrosine-protein kinase activity. Autophosphorylation activates the kinase activity. This Type I mebrane protein is composed of a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to th |
Immunogen | n/a |
Other Names | [Insulin receptor; IR; CD220; Insulin receptor subunit alpha; Insulin receptor subunit beta; INSR] |
Gene, Accession # | [INSR], Gene ID: 3643, NCBI: NP_000199.2, UniProt: P06213 |
Catalog # | MBS9212329 |
Price | $165, $370 |
Order / More Info | INSR (Insulin Receptor) (N-term), 21-52 Antibody from MYBIOSOURCE INC. |
Product Specific References | George, S., et al., Endocrinology 144(2):631-637 (2003). Longo, N., et al., Hum. Mol. Genet. 11(12):1465-1475 (2002). Hamer, I., et al., Diabetologia 45(5):657-667 (2002). Osawa, H., et al., Clin. Genet. 59(3):194-197 (2001). Rique, S., et al., Clin. Genet. 57(1):67-69 (2000). |