GITR / Tnfrsf18 (Mouse) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | GITR / Tnfrsf18 (Mouse) |
| Clone | [DTA-1] |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b, lambda |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAP's and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response. |
| Immunogen | Immunogen: Mouse CD25+ CD4+ T cells |
| Other Names | [Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18], [Tnfrsf18; Tnfrsf18; AITR; Gitr; Gitr] |
| Gene, Accession # | [Tnfrsf18], Gene ID: 21936, NCBI: NP_033426.1, UniProt: O35714 |
| Catalog # | MBS438739 |
| Price | $190, $340, $340 |
| Order / More Info | GITR / Tnfrsf18 (Mouse) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Stephens GL, et al. 2004. J. Immunol. 173:5008. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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