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Antigenic Specificity | RHOH |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Ess |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human RHOH (NP 004301.1). |
Other Names | [TTF; ARHH] |
Gene, Accession # | [RHOH], Gene ID: 399, NCBI: NP_004301.1, UniProt: Q15669 |
Catalog # | MBS8546037 |
Price | $280 |
Order / More Info | RHOH Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |