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Antigenic Specificity | XRCC6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total XRCC6 protein. Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The asse |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from C-terminal of human XRCC6. |
Other Names | [70 kDa subunit of Ku antigen; ATP-dependent DNA helicase II; 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75] |
Gene, Accession # | [XRCC6], Gene ID: 2547, NCBI: NP_001275905.1, UniProt: P12956 |
Catalog # | MBS9402915 |
Price | $200, $255 |
Order / More Info | XRCC6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |