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Antigenic Specificity | Phospho-Akt1 (Ser246) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB); Immunohistochemistry (IHC); Immunofluorescence (IF); ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal antibody to detect endogenous levels of Akt1 protein phosphorylated at S246 in human; mouse and rat. The serine/threonine kinase Akt family contains several members; including Akt1 (also designated PKB or RacPK); Akt2 and Akt 3; which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. They have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-? tyrosine residues 740 and 751; which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both resi |
Immunogen | Immunogen: Synthesized peptide derived from human ASK 1 around the phosphorylation site of S83; (20-100aa) |
Other Names | [AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha], [AKT1; PKB; RAC; PKB; PKB alpha] |
Gene, Accession # | [Akt1], Gene ID: 207, NCBI: NP_001014431.1, UniProt: P31749 |
Catalog # | MBS846123 |
Price | $335 |
Order / More Info | Phospho-Akt1 (Ser246) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |