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Antigenic Specificity | DIABLO |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human DIABLO (NP 063940.1). |
Other Names | [SMAC; DFNA64] |
Gene, Accession # | [DIABLO], Gene ID: 56616, NCBI: AAF87716.1, UniProt: Q9NR28 |
Catalog # | MBS8544994 |
Price | $280 |
Order / More Info | DIABLO Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |