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Antigenic Specificity | GABBR1 (N-Term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | humanpredicted: amphibian |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This GABBR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-52 amino acids from human GABBR1. Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysi |
Immunogen | n/a |
Other Names | [Purified Rabbit (Pab); Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1; GABBR1; GPRC3A] |
Gene, Accession # | [GABBR1], Gene ID: 2550, NCBI: NP_001461.1, UniProt: Q9UBS5 |
Catalog # | MBS9216245 |
Price | $165, $370 |
Order / More Info | GABBR1 (N-Term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Kaupmann K.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:14991-14996(1998).White J.H.,et al.Nature 396:679-682(1998).Stropp U.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.Grifa A.,et al.Biochem. Biophys. Res. Commun. 250:240-245(1998).Goei V.L.,et al.Biol. Psychiatry 44:659-666(1998). |