DR4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DR4 |
| Clone | [ABM1B11] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | fluorescein (FITC) conjugate |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediate oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promisi |
| Immunogen | Antigen: DR4. Immunogen Information: A partial length recombinant human DR4 protein (amino acids 2-203 was used as an immunogen for this antibody. Conjugation: FITC |
| Other Names | [TNFRSF10A; APO2; DR4; TRAILR1; Death receptor 4; TRAIL receptor 1; TNF-related apoptosis-inducing ligand receptor 1], [TNFRSF10A] |
| Gene, Accession # | [DR4], Gene ID: 8797, NCBI: NP_003835.3, UniProt: O00220 |
| Catalog # | MBS668933 |
| Price | $290 |
| Order / More Info | DR4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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