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Antigenic Specificity | Presenilin 1 (Phospho Ser357) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Presenilin 1 (S357) Polyclonal Antibody detects endogenous levels of Presenilin 1 protein only when phosphorylated at S357. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activ |
Immunogen | Immunogen: Synthesized peptide derived from human Presenilin 1 around the phosphorylation site of S357 |
Other Names | [Rabbit Presenilin 1 (phospho Ser357); AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182] |
Gene, Accession # | [PSEN1], Gene ID: 5663, NCBI: NP_000012.1, UniProt: P49768 |
Catalog # | MBS9706477 |
Price | $130, $220, $325 |
Order / More Info | Presenilin 1 (Phospho Ser357) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |