Edit |   |
---|---|
Antigenic Specificity | DAP Kinase 1 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 u |
Immunogen | Immunogen: A synthesized peptide derived from human DAP Kinase 1. Subcellular Localization: Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Colocalizes with MAP1B in the microtubules and cortical actin fibers. Tissue Specificity: Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas. |
Other Names | [Death-associated protein kinase 1; DAP kinase 1; 2.7.11.1; DAPK1; DAPK], [DAPK1; DAPK1; DAPK; ROCO3; DAPK; DAP kinase 1] |
Gene, Accession # | [DAPK1], Gene ID: 1612, NCBI: NP_001275658.1, UniProt: P53355 |
Catalog # | MBS179573 |
Price | $160, $340, $340 |
Order / More Info | DAP Kinase 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |