PAK1 (T423), 401-430 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PAK1 (T423), 401-430 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: bovine, mouse, rat, rabbit, Xenopus) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.43 |
| Applications | Western Blot (WB), ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This PAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from human PAK1. PAK1, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It is likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. The protein interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. PAK1 binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. It is a component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. The protein is autophosphory |
| Immunogen | n/a |
| Other Names | [Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK; PAK1] |
| Gene, Accession # | [PAK1], Gene ID: 5058, NCBI: NP_001122092.1, UniProt: Q13153 |
| Catalog # | MBS9208213 |
| Price | $165, $370 |
| Order / More Info | PAK1 (T423), 401-430 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Chen, S., et al., J. Biol. Chem. 278(22):20029-20036 (2003). Sells, M.A., et al., Curr. Biol. 7(3):202-210 (1997). Brown, J.L., et al., Curr. Biol. 6(5):598-605 (1996). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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