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Antigenic Specificity | E-Cadherin (CDH1)/CD324 (Intercellular Junction Marker) |
Clone | [CDH1/3256] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combin |
Immunogen | Immunogen: Recombinant fragment of human CDH1 protein (around aa 567-691) (exact sequence is proprietary) |
Other Names | [Arc 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependent adhesion protein; Liver cell adhesion molecule (LCAM); Uvomorulin (UVO)] |
Gene, Accession # | [CDH1], Gene ID: 999, NCBI: NP_004351.1, UniProt: P12830 |
Catalog # | MBS4381452 |
Price | $190, $340, $340 |
Order / More Info | E-Cadherin (CDH1)/CD324 (Intercellular Junction Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Jaggi M. et al. Cancer Res. 2005, 65: 483-492. 2. Rios-Doria, J et al. J. Biol. Chem 2003; 278: 372-1379. |