Human Chk2 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Human Chk2 antibody, protein, ELISA kits.
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| Antigenic Specificity | Human Chk2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Chk2 is the mammalian orthologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases (1-3). The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) each followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases (4,5). After DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR (5-7). The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 |
| Immunogen | Immunogen: A fusion protein of human Chk2 |
| Other Names | [Chk2 Rabbit pab], [CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53] |
| Gene, Accession # | [Chk2], Gene ID: 11200, NCBI: NP_001005735.1, UniProt: O96017 |
| Catalog # | MBS125011 |
| Price | $275, $430 |
| Order / More Info | Human Chk2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Allen, J.B. et al. (1994) Genes Dev. 8, 2401-2415. 2. Weinert, T.A. et al. (1994) Genes Dev. 8, 652-665. 3. Murakami, H. and Okayama, H. (1995) Nature 374, 817-819. 4. Kastan, M.B. and Lim, D.S. (2000) Nat. Rev. Mol. Cell Biol. 1, 179-186.5. Matsuoka, S. et al. (2000) Proc. Natl. Acad. Sci. USA 97, 10389-10394. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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