Retinoblastoma (Phospho-Thr826) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Retinoblastoma (Phospho-Thr826) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of Retinoblastoma only when phosphorylated at threonine 826. Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Contro |
| Immunogen | Immunogen Type: peptide Immunogen Description: Peptide sequence around phosphorylation site of threonine 826 (K-M-T(p)-P-R) derived from Human Retinoblastoma. |
| Other Names | [P105-RB; PP105; PP110; RB-1; RB1; Retinoblastoma-associated protein] |
| Gene, Accession # | Gene ID: 5925, NCBI: NP_000312.2, UniProt: P06400 |
| Catalog # | MBS9413711 |
| Price | $200, $255 |
| Order / More Info | Retinoblastoma (Phospho-Thr826) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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