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Antigenic Specificity | Dnmt1 - N-terminal region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against Dnmt1. It was validated on Western BlotTarget Description: Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/B |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of mouse Dnmt1 |
Other Names | [DNA (cytosine-5)-methyltransferase 1 isoform 2; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase MmuI; DNA MTase MmuI; M.MmuI; MCMT] |
Gene, Accession # | [DNMT1], Gene ID: 13433, NCBI: NP_034196, UniProt: P13864 |
Catalog # | MBS3203426 |
Price | $335 |
Order / More Info | Dnmt1 - N-terminal region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |