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Antigenic Specificity | TMEM59 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). |
Immunogen | Immunogen: Recombinant Human Transmembrane protein 59 protein (59-201AA) |
Other Names | [Transmembrane protein 59; Liver membrane-bound protein; TMEM59; C1orf8; HSPC001; UNQ169/PRO195] |
Gene, Accession # | [TMEM59], Gene ID: 9528, NCBI: NP_001291972.1, UniProt: Q9BXS4 |
Catalog # | MBS7103491 |
Price | $160, $235 |
Order / More Info | TMEM59 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |