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Antigenic Specificity | PPM1D |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total PPM1D protein. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression o |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human PPM1D. |
Other Names | [WIP1; PP2C-DELTA] |
Gene, Accession # | [PPM1D], Gene ID: 8493, NCBI: NP_003611.1, UniProt: O15297 |
Catalog # | MBS9406653 |
Price | $255 |
Order / More Info | PPM1D Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |