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Antigenic Specificity | Hrk BH3 Domain, 15-50 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This Hrk BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-50 amino acids from human Hrk BH3 Domain. Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL. |
Immunogen | n/a |
Other Names | [Activator of apoptosis harakiri; BH3-interacting domain-containing protein 3; Neuronal death protein DP5; HRK; BID3] |
Gene, Accession # | [HRK], Gene ID: 8739, NCBI: NP_003797.1, UniProt: O00198 |
Catalog # | MBS9212528 |
Price | $165, $370 |
Order / More Info | Hrk BH3 Domain, 15-50 Antibody from MYBIOSOURCE INC. |
Product Specific References | Wakabayashi, T., et al., Neurosci. Lett. 318(2):77-80 (2002). Inohara, N., et al., EMBO J. 16(7):1686-1694 (1997). |