Casp12 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Casp12 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to casp12. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels (1,2). One of the mechanisms for caspase-12 activation is related to calpain mediated cleavage at T132 and K158, both of which are located at the amino-terminal region of the caspase-12 (2,3). Caspase-12 also has a putative caspase cleavage site located at the carboxy-terminal region of the protein (3). In cortical neurons, caspase-12 is involved at least partially in the amyloid-beta neurotoxicity process (1). |
| Immunogen | Immunogen: A synthetic -peptide of human casp12 |
| Other Names | [CASP12; Casp12; Inactive caspase 12; Caspase12; caspase 12 (gene/pseudogene); CASP12P1; CASP12], [CASP12; CASP12; CASP-12; CASP12P1; CASP-12] |
| Gene, Accession # | Gene ID: 100506742, NCBI: NP_001177945.1, UniProt: Q6UXS9 |
| Catalog # | MBS126103 |
| Price | $200, $275, $430 |
| Order / More Info | Casp12 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nakagawa, T. et al. (2000) Nature 403, 98-103. 2. Nakagawa, T. and Yuan, J. (2000) J. Cell Biol. 150, 887-894. 3. Van de Craen, M. et al. (1997) FEBS Lett. 403, 61-69. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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