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Antigenic Specificity | RASSF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 101-340 of human RASSF1 (NP 009113.3). |
Other Names | [123F2; RDA32; NORE2A; RASSF1A; REH3P21] |
Gene, Accession # | [RASSF1], Gene ID: 11186, NCBI: Q9NS23.1, UniProt: Q9NS23 |
Catalog # | MBS8544307 |
Price | $280 |
Order / More Info | RASSF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |