Elastase/ELANE/ELA2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Elastase/ELANE/ELA2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit IgG polyclonal antibody for Neutrophil elastase(ELANE) detection. Background: Neutrophil elastase is a serine protease of neutrophil and monocyte granules. Its key physiologic role is in innate host defense, but it can also participate in tissue remodeling and possesses secretagogue actions important to local inflammatory responses. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins o |
| Immunogen | Immunogen: E. coli-derived mouse Elastase/ELANE/ELA2 recombinant protein (Position: S27-N265). Mouse Elastase/ELANE/ELA2 shares 92% amino acid (aa) sequence identity with rat Elastase/ELANE/ELA2. |
| Other Names | [ELA2; ELANE; Elastase 2; Elastase-2; HLE; HNE; Leukocyte elastase; Medullasin; Neutrophil elastase; PMN E; PMN elastase; SCN1; P08246; elastase, neutrophil expressed], [Elane; Elane; NE; Ela2; F430011M15Rik; Ela2] |
| Gene, Accession # | [ELANE], Gene ID: 50701, NCBI: NP_056594.2, UniProt: Q3UP87 |
| Catalog # | MBS178814 |
| Price | $315 |
| Order / More Info | Elastase/ELANE/ELA2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Ancliff, P. J., Gale, R. E., Liesner, R., Hann, I. M., Linch, D. C.Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease. Blood 98: 2645-2650, 2001.2. Bristow, C. L., Fiscus, S. A., Flood, P. M., Arnold, R. R. Inhibition of HIV-1 by modification of a host membrane protease. Int. Immun. 7: 239-249, 1995. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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