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Antigenic Specificity | Human IL-21 |
Clone | [SB134f] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.5 mg |
Concentration | n/a |
Applications | ELISA |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reacts with human IL-21. Interleukin-21 (IL-21) is a four helical bundle type I cytokine1. The mature form of human IL-21 is a 131 amino acid protein.4 IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of Tcells and augmentation of antitumor activity of CD8+ T cells.2, 3 Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treat |
Immunogen | Immunogen: Recombinant human IL-21. Characterization: To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent. |
Other Names | [Mouse Human Interleukin-21 (IL-21)], [IL21; IL21; Za11; IL-21; IL-21] |
Gene, Accession # | Gene ID: 59067, NCBI: NP_001193935.1, UniProt: Q9HBE4 |
Catalog # | MBS670185 |
Price | $265 |
Order / More Info | Human IL-21 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1) Rosanne Spolski and Warren J. Leonard (2008). Annu Rev Immunol 29:57-79.2) Ettinger, R., et al. (2005). J. Immunol. 175:7867-7879.3) Kuchen, S., et al. (2007). J. Immunol. 179:5886-5896.4) Parrish-Novak, J. et al. (2000). Nature. 408:57-63. |