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Antigenic Specificity | MAPK10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total MAPK10 protein. The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists (1-6). As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase (2). Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42) (3). Both Rac1 and cdc42 mediate the stimulatio |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human MAPK10. |
Other Names | [FLJ12099; FLJ33785; JNK3; JNK3A; MGC50974] |
Gene, Accession # | [MAPK10], Gene ID: 5602, NCBI: NP_002744.1, UniProt: P53779 |
Catalog # | MBS9410533 |
Price | $255 |
Order / More Info | MAPK10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |