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Antigenic Specificity | Human CD45RO |
Clone | [UCHL1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, kappa |
Format | unconjugated |
Size | 0.025 mg, 0.1 mg |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines. |
Immunogen | n/a |
Other Names | [receptor-type tyrosine-protein phosphatase C isoform 1; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; protein tyrosine phosphatase receptor type C; Leukocyte common antigen; L-CA; T200] |
Gene, Accession # | [CD45RO], Gene ID: 5788, NCBI: NP_002829.3, UniProt: P08575 |
Catalog # | MBS2559015 |
Price | $60, $90 |
Order / More Info | Human CD45RO Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |