Human IGFBP-3 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Human IGFBP-3 |
| Clone | [SBH10] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | Protein A purified |
| Size | 0.5 mg, 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IGFBPs are synthesized in the liver and are produced also by various tumor cell lines and cell types. IGFBPs are high affinity binding proteins for IGF. The major fraction of both types of IGF circulating in the blood are bound non- covalently to these carrier proteins. IGF binding proteins modulate IGF activities by increasing their plasma half lives and by inhibiting or promoting the interactions of IGF with receptors on certain target cells. In addition these binding proteins provide a reservoir for IGF in pericellular spaces. Some IGFBPs also have stimulating effects in vitro and some may inhibit the growth of cells. IGFBP1 is found predominantly in the placenta and the amniotic fluid. The predominant sites of IGFBP1 transcription in th |
| Immunogen | Host Note: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human IGFBP-3. |
| Other Names | [igfbp3; igfbp-3;; mab], [IGFBP3; IBP3; IBP-3; IGF-binding protein 3; IGFBP-3] |
| Gene, Accession # | [IGFBP-3], Gene ID: 3486, NCBI: NP_000589.2, UniProt: P17936 |
| Catalog # | MBS550042 |
| Price | $550, $855 |
| Order / More Info | Human IGFBP-3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | • randomized gh trial with two different dosages in combination with a gnrh analogue in short sga children: effects on metabolic profile, serum growth hormone, igf-i and IGFBP-3 levels.Eur. J. Endocrinol., Feb 2010; 10.1530/EJE-09-1113. • nuclear export and mitochondrial and er localization of IGFBP-3 regulates its apoptotic properties.Endocr. Relat. Cancer, Jan 2010; 10.1677/ERC-09-0106. • association between hepatic steatosis and serum igf1 and IGFBP-3 levels in a population-based sample.Eur. J. Endocrinol., Nov 2009; 161: 705 - 713. • the expression and function of IGFBP-3 in normal and malignant breast tissue.Anticancer Res, Oct 2009; 29: 3785 - 3790. • prognostic role of insulin-like growth factor receptor-1 (igfr-1) and insulin-like growth factor binding protein-3 (IGFBP-3) expression in small cell lung cancer.ASCO Meeting Abstracts, May 2009; 27: e22155. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
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