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Antigenic Specificity | HP-1gamma |
Clone | [6F7-6A3-2B10] |
Host Species | Mouse |
Reactive Species | human, rat, mouse |
Isotype | IgG1 |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement |
Immunogen | Immunogen: Purified recombinant protein expressed in E Coli. |
Other Names | [CBX3; Chromobox homolog 3; HECH; HP1 gamma; CBX3] |
Gene, Accession # | [HP-1gamma], Gene ID: 11335, NCBI: NP_009207.2, UniProt: Q13185 |
Catalog # | MBS8539826 |
Price | $280 |
Order / More Info | HP-1gamma Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |