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Antigenic Specificity | WAS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in car |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [WAS; IMD2; THC; THC1; WASP], [WAS; WAS; THC; IMD2; SCNX; THC1; WASP; IMD2; WASp] |
Gene, Accession # | [WAS], Gene ID: 7454, NCBI: P42768.4, UniProt: P42768 |
Catalog # | MBS127276 |
Price | $200, $275, $430 |
Order / More Info | WAS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |