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Antigenic Specificity | DDX21 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitati |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 624-783 of human DDX21 (NP 004719.2). |
Other Names | [GUA; GURDB; RH-II/GU; RH-II/GuA] |
Gene, Accession # | [DDX21], Gene ID: 9188, NCBI: Q9NR30.5, UniProt: Q9NR30 |
Catalog # | MBS8550183 |
Price | $280 |
Order / More Info | DDX21 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |