CD104 (Integrin Beta-4) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | CD104 (Integrin Beta-4) |
| Clone | [UM-A9] |
| Host Species | Mouse |
| Reactive Species | human. |
| Isotype | IgG2a, kappa |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Biological Blockade, ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in thi |
| Immunogen | Immunogen: Human squamous cell carcinoma (UM-SCC1) Quantity and Buffer: 0.5 ml at 200ug/ml with BSA and azide |
| Other Names | [GP150; Integrin beta-4; ITGB4], [ITGB4; ITGB4; CD104] |
| Gene, Accession # | [ITGB4], Gene ID: 3691, NCBI: NP_000204.3, UniProt: P16144 |
| Catalog # | MBS438251 |
| Price | $190, $340, $340 |
| Order / More Info | CD104 (Integrin Beta-4) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG. EMBO J. 1995;14(18):4470-81.2. The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4. Van Waes C, Kozarsky KF, Warren AB, Kidd L, Paugh D, Liebert M, Carey TE. Cancer Res. 1991;51(9):2395-402.3. Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9. Kimmel KA, Carey TE. Cancer Res. 1986 Jul;46(7):3614-23. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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