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Antigenic Specificity | MLL3 (C-term), 4345-4374 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 1 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4345-4374 amino acids from the C-terminal region of human MLL3. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL3. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. MLL3 maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. The deduced MLL3 4,911-amino acid protein is more closely related to MLL2 than to MLL1 or MLL4. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus; a high mobility group (HMG) box, an ATPase alpha-beta signature, and |
Immunogen | n/a |
Other Names | [Histone-lysine N-methyltransferase 2C; Lysine N-methyltransferase 2C; Homologous to ALR protein; Myeloid/lymphoid or mixed-lineage leukemia protein 3; KMT2C; HALR; KIAA1506; MLL3] |
Gene, Accession # | [KMT2C], Gene ID: 58508, NCBI: NP_733751.2, UniProt: Q8NEZ4 |
Catalog # | MBS9212130 |
Price | $165, $370 |
Order / More Info | MLL3 (C-term), 4345-4374 Antibody from MYBIOSOURCE INC. |
Product Specific References | Ota, T., et al., Nat. Genet. 36(1):40-45 (2004). Hillier, L.W., et al., Nature 424(6945):157-164 (2003). Goo, Y.-H., et al., Mol. Cell. Biol. 23(1):140-149 (2003). Tan, Y.C., et al., Cancer Detect. Prev. 25(5):454-469 (2001). Nagase, T., et al., DNA Res. 7(2):143-150 (2000). |