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Antigenic Specificity | Phospho-MAPKAP Kinase 2 (Thr334) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects endogenous levels of MAPKAP Kinase 2 only when phosphorylated at threonine 334 (human) and threonine 320 (mouse and rat). Function: Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X2-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, |
Immunogen | Immunogen: Synthetic phosphopeptide from around the phosphorylation site of threonine 334 (PQTPPL) of human MAPKAP Kinase 2 Subcellular Location: Cytoplasmic and Nuclear Tissue Specificity: Expressed in all tissues examined. |
Other Names | [MAP kinase activated protein Kinase 2; MAP kinase-activated protein kinase 2; MAPK activated protein kinase 2; MAPK-activated protein kinase 2; MAPK2_HUMAN; MAPKAP K2; MAPKAP kinase 2; MAPKAPK 2; MAPKAPK-2; MAPKAPK2; Mitogen activated protein kinase activated protein kinase 2; MK 2; MK2] |
Gene, Accession # | [MAPKAPK2], Gene ID: 9261, NCBI: NP_004750.1, UniProt: P49137 |
Catalog # | MBS9608228 |
Price | $240, $280 |
Order / More Info | Phospho-MAPKAP Kinase 2 (Thr334) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |