NGFR Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityNGFR
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionThe p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is distinguished by multiple cysteine-rich ligand-binding domains, a single transmembrane sequence and a noncatalytic cytoplasmic domain (1). p75NTR displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, p75NTR recognizes neurotrophins and transmits trophic signals into the cell. Both p75NTR and TrkA are required to activate PI3K-Akt signaling, while TrkA can individually activate the MAP kinase pathway. In contrast, p75NTR, possibly through JNK, ensures appropriate apoptosis of injured neurons and improperly targeted neonatal neurons (2).The p75NTR protein undergoes sequential cleavage similar
ImmunogenImmunogen: A synthetic peptide of human NGFR Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[CD271; Gp80-LNGFR; TNFRSF16; p75(NTR); p75NTR]
Gene, Accession #[NGFR], Gene ID: 4804, NCBI: NP_002498.1, UniProt: P08138
Catalog #MBS8505153
Price$310
Order / More InfoNGFR Antibody from MYBIOSOURCE INC.
Product Specific References1. Chao, M.V. (2003) Nat. Rev. Neurosci. 4, 299-309. 2. Nykjaer, A. et al. (2005) Curr. Opin. Neurobiol. 15, 49-57. 3. Kanning, K.C. et al. (2003) J. Neurosci. 23, 5425-5436. 4. Jung, K.M. et al. (2003) J. Biol. Chem. 278, 42161-42169.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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