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Antigenic Specificity | Human Pregnancy-specific-protein (PSG) |
Clone | [BAP3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunohistochemistry(IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: anti-human PSG (CD 66f); epitope in the B2 domain (present in most PSG). Background: The human pregnancy-specific glycoprotein family (PSG) is a group of closely related secreted glycoproteins which are highly expressed in placental syncytiotrophoblast cells of fetal origin (1). PSG are commonly expressed in tumors of trophoblast origin (hydatidiform mole, choriocarcinoma). They represent the most abundant fetal protein in the maternal blood at term. Together with the carcinoembryonic antigen (CEA)-related cell adhesion molecule (CEACAM) genes, the human PSG genes form the CEACAM gene family (2). PSG stimulate secretion of TH2-type cytokines from monocytes. CD9 was shown to represent the monocyte receptor for murine PSG17 (3). |
Immunogen | Immunogen: Immunogen: extracted protein of human PSG |
Other Names | [pregnancy-specific glycoprotein 1; CD66f], [PSG1; PSG1; SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1; B1G1; PSBG1; PSGGA; PS-beta-G-1; PSBG-1; Pregnancy-specific glycoprotein 1; FL-NCA-1/2; PS-beta-C/D] |
Gene, Accession # | Gene ID: 5669, NCBI: NP_001171754.1, UniProt: P11464 |
Catalog # | MBS468004 |
Price | $505 |
Order / More Info | Human Pregnancy-specific-protein (PSG) Antibody from MYBIOSOURCE INC. |
Product Specific References | Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, Hammarstrom S, Holmes KV,Karlsson A, Kuroki M, Lin SH, Lucka L, Najjar SM, Neumaier M, Obrink B, Shively JE, Skubitz KM,Stanners CP, Thomas P, Thompson JA, Virji M, von Kleist S, Wagener C, Watt S and Zimmermann W(1999). Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res 252:243-249.Hammarstrom S (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions andexpression in normal and malignant tissues. Semin Cancer Biol 9: 67-81.Snyder SK, Wessner DH, Wessells JL, Waterhouse RM, Wahl LM, Zimmermann W and Dveksler GS(2001). Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6and TGF-beta1 by human monocytes. Am J Reprod Immunol 45: 205-216.Sokolov AV, Kozliaeva GA, Mesniankina NV and Tatarinov I (1978). [Isolation and purification of specificbeta1-G-globulin]. Vopr Med Khim 24: 240-244.Zhou GQ, Baranov V, Zimmermann W, Grunert F, Erhard B, Mincheva-Nilsson L, Hammarstrom Sand Thompson J (1997). Highly specific monoclonal antibody demonstrates that pregnancy- specificglycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta. Placenta 18: 491-501. |