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Antigenic Specificity | synaptophysin 2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total synaptophysin 2 protein. Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2. |
Other Names | [Synpr] |
Gene, Accession # | Gene ID: 66030, NCBI: NP_076464.1, UniProt: P22831 |
Catalog # | MBS9406369 |
Price | $200, $255 |
Order / More Info | synaptophysin 2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |