FAK (Tyr-397), phospho-specific, Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-FAK (Tyr-397), phospho-specific, antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | FAK (Tyr-397), phospho-specific, |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse, rabbit |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects a 125 kDa* protein on SDS-PAGE immunoblots of untreated HUVEC cells. This phosphorylated band is greatly reduced after treatment with alkaline phosphatase. Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in signal transduction pathways important for cell spreading, migration and survival. Activation of FAK by integrin clustering leads to autophosphorylation at Tyr-397, which is a binding site for Src family kinases, PI3-Kinase, and PLC-gamma. The recruitment of Src family kinases results in the phosphorylation of tyrosine 407, 576, and 577 in the catalytic domain, and tyrosine 871 and 925 in the carboxy-terminal region of FAK. Thus, the phosphorylation of Tyr-397 is a criti |
| Immunogen | Immunogen: Clone (M121) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 397 of human FAK.This peptide sequence has high homology to the conserved tyrosine site in rat and mouse FAK. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS470013 |
| Price | $385 |
| Order / More Info | FAK (Tyr-397), phospho-specific, Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Cobb, B.S. et al. (1994) Mol. Cell. Biol. 14:147.• Parsons, J.T. et al. (2000) Oncogene 19:5606.• Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14:1680.• Schlaepfer, D.D. et al. (1994) Nature 372:786-791. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies