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Antigenic Specificity | BMI1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest (1-4). PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27. This histone methyl-transferase activity requires the Ezh2, Eed, and Suz12 subunits of the complex (5). Histone H3 methylation at Lys27 facilitates the recruitment of the second complex, PRC1, which ubiquitinylates histo |
Immunogen | Immunogen: Recombinant protein of human BMI1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [BMI1; Polycomb complex protein BMI 1; RING finger protein 51; RNF51; PCGF4] |
Gene, Accession # | [BMI1], Gene ID: 100532731, NCBI: NP_001190991.1, UniProt: P35226 |
Catalog # | MBS8505685 |
Price | $310 |
Order / More Info | BMI1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Boyer, L.A. et al. (2006) Nature 441, 349-53. 2. Lee, T.I. et al. (2006) Cell 125, 301-13. 3. Park, I.K. et al. (2003) Nature 423, 302-5. 4. Molofsky, A.V. et al. (2003) Nature 425, 962-7. 5. Cao, R. and Zhang, Y. (2004) Mol Cell 15, 57-67. 6. Wang, H. et al. (2004) Nature 431, 873-8. 7. Cao, R. et al. (2005) Mol Cell 20, 845-54. 8. Molofsky, A.V. et al. (2005) Genes Dev 19, 1432-7. 9. Jacobs, J.J. et al. (1999) Nature 397, 164-8. 10. Jacobs, J.J. et al. (1999) Genes Dev 13, 2678-90. |