Edit |   |
---|---|
Antigenic Specificity | PKCalpha |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total PKCa protein. Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.645-649(I-A-N-I-D) derived from Human PKCa. |
Other Names | [PKCa; AAG6, PKCA, PRKACA, PKC-alpha,] |
Gene, Accession # | [PKCalpha], Gene ID: 5578, NCBI: NP_002728.1 |
Catalog # | MBS9403544 |
Price | $200, $255 |
Order / More Info | PKCalpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |