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Antigenic Specificity | CD40 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, monkey, porcine |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.2 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center thromugh interaction with T cells expressing CD40L, and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells, CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6, a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its |
Immunogen | Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 261 of human CD40 |
Other Names | [CDW40; CDw40; p50; Bp50; MGC9013; TNFRSF5], [CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5] |
Gene, Accession # | [CD40], Gene ID: 958, NCBI: NP_001241.1, UniProt: P25942 |
Catalog # | MBS840837 |
Price | $150, $305 |
Order / More Info | CD40 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |