AKT1/3 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityAKT1/3
Clone[AT6D5]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2a, k
FormatProtein A purified
Size0.05 mL, 0.1 mL
Concentration1 mg/ml
ApplicationsELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
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DescriptionAKT1, also known as RAC-alpha serine/threonine-protein kinase, is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
ImmunogenImmunogen: Recombinant human AKT1 (1-480aa) purified from insect cell.
Other Names[RAC-alpha serine/threonine-protein kinase; AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA], [AKT1; AKT1; AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA; PKB; RAC; PKB; PKB alpha]
Gene, Accession #[AKT1/3], Gene ID: 207, NCBI: NP_001014432, UniProt: P31749
Catalog #MBS206596
Price$240, $315
Order / More InfoAKT1/3 Antibody from MYBIOSOURCE INC.
Product Specific ReferencesLindhurst MJ, et al (2011) N Engl J Med. 365 (7): 611-9.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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