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Antigenic Specificity | Human CASPASE-1 (C-TERMINAL) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1.0 mg/ml |
Applications | Immunohistology Paraffin*, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti Human Caspase-1 antibody recognizes an epitope within the C-terminal region (CT) of human Caspase-1, otherwise known as IL-1Beta converting enzyme. Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. Regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases (Ghayur et al. 1997). Rabbit anti Human Caspase-1 an |
Immunogen | Perservative Stabilisers: 0.02% Sodium Azide. Preparation: Antisera to human Caspase-1 (CT) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography. |
Other Names | [caspase-1 isoform beta; Caspase-1; caspase-1; CASP1 nirs variant 1; IL-1 beta-converting enzyme; IL1B-convertase; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Cleaved into the following 2 chains:Caspase-1 subunit p20; Caspase-1 subunit p10], [CASP1; CASP1; ICE; P45; IL1BC; IL1BC; IL1BCE; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme] |
Gene, Accession # | Gene ID: 834, NCBI: NP_001214.1, UniProt: P29466 |
Catalog # | MBS221844 |
Price | $375 |
Order / More Info | Human CASPASE-1 (C-TERMINAL) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |