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Antigenic Specificity | GNA12 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GNA12 antibody detects endogenous levels of total GNA12. Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target protein |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Membrane. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog Similarity: Pig (91%), Bovine (91%), Horse (91%), Sheep (100%), Rabbit (91%), Dog (91%) |
Other Names | [G alpha 12; G alpha-12; G-protein subunit alpha-12; gep; Gna12; GNA12_HUMAN; guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide binding protein alpha 12 subunit; Guanine nucleotide-binding protein subunit alpha-12; MGC104623; MGC99644; NNX3; RMP; WUGSC:H_GS165O14.2] |
Gene, Accession # | [GNA12], Gene ID: 2768, NCBI: NP_001269370.1, UniProt: Q03113 |
Catalog # | MBS9603741 |
Price | $240, $280 |
Order / More Info | GNA12 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |