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Antigenic Specificity | TFEB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Speci |
Immunogen | Immunogen: Recombinant Human Transcription factor EB protein (1-476AA) |
Other Names | [Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35; TFEB; BHLHE35] |
Gene, Accession # | [TFEB], Gene ID: 7942, NCBI: NP_001161299.2, UniProt: P19484 |
Catalog # | MBS7049265 |
Price | $160, $235 |
Order / More Info | TFEB Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |