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Antigenic Specificity | RAD50 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA, Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total RAD50 protein. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthetic peptide corresponding to a region derived from 325-339 amino acids of Human RAD50 homolog (S. cerevisiae) |
Other Names | [RAD50 homolog (S. cerevisiae), NBSLD, RAD502, hRad50] |
Gene, Accession # | [RAD50], Gene ID: 10111, NCBI: NP_005723 |
Catalog # | MBS9403781 |
Price | $200, $255 |
Order / More Info | RAD50 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |