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Antigenic Specificity | TTF-1/NKX2.1 (Thyroid & Lung Epithelial Marker) |
Clone | [rNX2.1/690] |
Host Species | Mouse |
Reactive Species | human, mouse, rat. |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive |
Immunogen | Immunogen: Recombinant full-length TTF-1 protein Cellular Localization: Nuclear |
Other Names | [BCH; Benign chorea; BHC; Homeobox protein Nkx2.1; NK2 homeobox 1; NKX2.1; NKX2A; TEBP; Thyroid nuclear factor-1; Thyroid specific enhancer binding protein; Thyroid transcription factor-1 (TTF-1); Tin man; TITF1; TTF-1] |
Gene, Accession # | [TTF-1], Gene ID: 7080, NCBI: NP_001073136.1, UniProt: P43699 |
Catalog # | MBS4380257 |
Price | $190, $340, $340 |
Order / More Info | TTF-1/NKX2.1 (Thyroid & Lung Epithelial Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Wert, S.E., et al. 2002. Increased expression of TTF-1 in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation. Dev. Biol. 242: 75-87. |