COT (MAP3K8/MEKK8) (C-term), 368-397 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | COT (MAP3K8/MEKK8) (C-term), 368-397 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: mouse, rat) |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This COT (MAP3K8/MEKK8) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-397 amino acids from the C-terminal region of human COT (MAP3K8/MEKK8). COT, a member of the MAPKKK subfamily of Ser/Thr protein kinases, is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. It plays a role in the cell cycle. The longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on S |
| Immunogen | n/a |
| Other Names | [Mitogen-activated protein kinase kinase kinase 8; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; Tumor progression locus 2; TPL-2; MAP3K8; COT; ESTF] |
| Gene, Accession # | [MAP3K8], Gene ID: 1326, NCBI: NP_001231063.1, UniProt: P41279 |
| Catalog # | MBS9211630 |
| Price | $165, $370 |
| Order / More Info | COT (MAP3K8/MEKK8) (C-term), 368-397 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Sanchez-Gongora, E., et al., J. Biol. Chem. 275(40):31379-31386 (2000). Aoki, M., et al., J. Biol. Chem. 268(30):22723-22732 (1993). Chan, A.M., et al., Oncogene 8(5):1329-1333 (1993). Miyoshi, J., et al., Mol. Cell. Biol. 11(8):4088-4096 (1991). Aoki, M., et al., Oncogene 6(9):1515-1519 (1991). |
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MYBIOSOURCE INC.
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